Santos Laguna vs Atletico San Luis: Prediction, Betting Tips & Match Preview – 21 September

Santos Laguna

L W D W L

11th place in Clausura

1-4

21/09/2025 19:00

Atletico San Luis

L W W L L

15th place in Clausura

Primera Division de Mexico

MATCH INTRO

Betiball's prediction for Santos Laguna vs Atletico San Luis on 21 September 2025 (kick-off: 19:00) is built from both teams' recent form, head-to-head history, squad availability, and tactical analysis. Read the full Santos Laguna vs Atletico San Luis preview before placing your bet.

Santos Laguna are currently 11th with 20 points after 17 matches.
Atletico San Luis sit 15th with 16 points from 17 matches.
Our algorithm prediction: Santos Laguna to win with probability 40%.
Head-to-head history favors Atletico San Luis, who have won 3 of the last 6 meetings. Santos Laguna have 2 wins, while one match ended in a draw.

Predictions 1x2 Under/Over 2.5 1X2 Live Half Time Half Time / Full Time Both To Score Double chance Handicap Scorers Corners Cards

Home team Away team

Probability %

Pred

Correct

Avg.g

Coef.

Score.

Live coef.

Weather

19:00

2025-09-21

Santos Laguna vs Atletico San Luis - Prediction & Odds

Santos Laguna

Atletico San Luis

2025-09-21 19:00

STANDINGS UP TO 21/09/2025

Clausura	PTS	GP	W	D	L	GF	GA	+/-

01 Toluca	37	17	11	4	2	43	18	25
02 Tigres UANL	36	17	10	6	1	35	16	19
03 CDSyC Cruz Azul	35	17	10	5	2	32	20	12
04 Club America	34	17	10	4	3	33	18	15
05 Monterrey	31	17	9	4	4	33	29	4
06 Chivas Guadalajara	29	17	9	2	6	29	22	7
07 Club Tijuana	24	17	6	6	5	29	23	6
08 FC Juarez	23	17	6	5	6	27	28	-1
09 Pachuca	22	17	6	4	7	21	21	0
10 Pumas U.N.A.M.	21	17	5	6	6	24	25	-1
11 Santos Laguna	20	17	6	2	9	22	28	-6
12 Queretaro FC	20	17	6	2	9	19	29	-10
13 Necaxa	17	17	4	5	8	24	32	-8
14 Atlas	17	17	4	5	8	24	35	-11
15 Atletico San Luis	16	17	5	1	11	25	29	-4
16 Mazatlan FC	14	17	2	8	7	20	29	-9
17 Club Leon	13	17	3	4	10	14	31	-17
18 Puebla	12	17	3	3	11	21	42	-21

Apertura	PTS	GP	W	D	L	GF	GA	+/-

01 Pumas U.N.A.M.	36	17	10	6	1	34	17	17
02 Chivas Guadalajara	36	17	11	3	3	33	17	16
03 CDSyC Cruz Azul	33	17	9	6	2	31	18	13
04 Pachuca	31	17	9	4	4	25	19	6
05 Toluca	30	17	8	6	3	28	16	12
06 Atlas	26	17	7	5	5	16	18	-2
07 Tigres UANL	25	17	7	4	6	28	18	10
08 Club America	25	17	7	4	6	20	17	3
09 Club Tijuana	23	17	5	8	4	19	17	2
10 Club Leon	22	17	7	1	9	22	32	-10
11 Queretaro FC	20	17	4	8	5	17	21	-4
12 FC Juarez	19	17	5	4	8	26	32	-6
13 Monterrey	18	17	5	3	9	22	24	-2
14 Atletico San Luis	18	17	5	3	9	24	27	-3
15 Necaxa	18	17	5	3	9	19	25	-6
16 Mazatlan FC	15	17	4	3	10	22	37	-15
17 Puebla	13	17	3	4	10	13	26	-13
18 Santos Laguna	12	17	3	3	11	20	38	-18

Head To Head

30/03/2025 19:00

Santos Laguna

2 - 3

Atletico San Luis

MEX D1

28/09/2024 23:10

Atletico San Luis

3 - 1

Santos Laguna

MEX D1

28/04/2024 20:00

Santos Laguna

0 - 3

Atletico San Luis

MEX D1

11/11/2023 19:00

Atletico San Luis

0 - 2

Santos Laguna

MEX D1

18/02/2023 19:00

Atletico San Luis

1 - 1

Santos Laguna

MEX D1

28/08/2022 20:10

Santos Laguna

4 - 1

Atletico San Luis

MEX D1

Santos Laguna

33%

Draw

17%

Atletico San Luis

50%

Santos Laguna Last 6 matches

13/09/2025 21:00

Atlas 2 - 2 Santos Laguna MEX D1

30/08/2025 21:00

Santos Laguna 0 - 1 Tigres UANL MEX D1

22/08/2025 21:00

FC Juarez 2 - 1 Santos Laguna MEX D1

16/08/2025 21:00

CDSyC Cruz Azul 3 - 2 Santos Laguna MEX D1

10/08/2025 22:10

Santos Laguna 1 - 0 Chivas Guadalajara MEX D1

07/08/2025 23:50

Los Angeles Galaxy 4 - 0 Santos Laguna NCAL Cup

Win

17%

Draw

17%

Lost

67%

Last 6 matches Atletico San Luis

14/09/2025 21:00

Atletico San Luis 1 - 1 Club Tijuana MEX D1

29/08/2025 21:00

Atletico San Luis 1 - 3 Toluca MEX D1

22/08/2025 21:00

Queretaro FC 3 - 2 Atletico San Luis MEX D1

15/08/2025 21:00

Puebla 0 - 2 Atletico San Luis MEX D1

11/08/2025 23:10

Atletico San Luis 1 - 2 CDSyC Cruz Azul MEX D1

06/08/2025 20:30

Minnesota United FC 0 - 2 Atletico San Luis NCAL Cup

Win

33%

Draw

17%

Lost

50%

Overall Home/Away

Full time First half Second half

All leagues Primera Division de Me...

Played games

Santos Laguna

Atletico San Luis

Goals

Scored

Avg. per game

1.47

Conceded

Avg. per game

1.29

Scored

Avg. per game

1.35

Conceded

Avg. per game

1.53

Scored a goal

In last 6 home matches

YesNo

5 (83%)1 (17%)

In last 6 home matches

NoYes

4 (67%)2 (33%)

In last 17 home matches

YesNo

15 (88%)2 (12%)

In last 17 home matches

NoYes

13 (76%)4 (24%)

Santos Laguna

Recent matches

Atletico San Luis

Under /Over

(71%)12 5(29%)

1.5

Full Time

Under /Over

(82%)14 3(18%)

Under /Over

(29%)5 12(71%)

1.5

1st Half

Under /Over

(24%)4 13(76%)

Under /Over

(47%)8 9(53%)

1.5

2nd Half

Under /Over

(53%)9 8(47%)

/Yes

(53%)9 8(47%)

Both scored
(Yes/No)

No /Yes

(59%)10 7(41%)

GOALS BY TIME PERIOD

Santos Laguna

Atletico San Luis

Shots

Santos Laguna

Total shots

7.88 avg / game

Blocked

31 total

Avg. 2.21

Atletico San Luis

Total shots

9.82 avg / game

Blocked

45 total

Avg. 3.21

Santos Laguna Pass Atletico San Luis

Total passes

3566

Avg. 210 / game

Accurate

77%

Ball possession

44%

Total passes

5649

Avg. 332 / game

Accurate

81%

Ball possession

49%

TOTAL ATTACKS

DANGEROUS ATTACKS

OTHERS

Santos Laguna

Played games

Atletico San Luis

Avg / game Total Total Avg / game

0.35

Clean sheets

0.18

2.82

Corners

4.00

14.24

242

Throw-ins

318

18.71

1.29

Offsides

0.82

3.24

GK saves

2.53

Santos Laguna

DISCIPLINARY

Atletico San Luis

Avg / game Total Total Avg / game

2.12

1.82

0.35

0.12

9.76

166

Fouls

188

11.06

7.06

120

Tackles

113

6.65

NEXT MATCHES

NEXT MATCHES

How We Build the Santos Laguna vs Atletico San Luis Prediction

Betiball.com's prediction for Santos Laguna vs Atletico San Luis on 21 September 2025 is generated by a statistical model that processes over 30 data points per match — including each team's last ten results, expected goals (xG), shots on target, defensive line metrics, set-piece vulnerability, and confirmed squad availability. For this Primera Division de Mexico fixture, our model also factors in home and away performance splits and any confirmed injuries or suspensions reported within 48 hours of kick-off. Every tip includes a probability percentage — not just a pick, but the data behind it.

Santos Laguna vs Atletico San Luis Form Analysis

Heading into this match, both sides carry distinct statistical profiles our model weighs carefully. We assess Santos Laguna's recent home record, scoring rate, and clean sheet frequency against Atletico San Luis's away form — particularly goals conceded on the road and their tendency to score or keep clean sheets in away fixtures. Over/Under 2.5 goals, Both Teams to Score (BTTS), and the Asian Handicap line are all evaluated through this lens before a final recommendation is issued.

Primera Division de Mexico Context: Standings, Form & What's at Stake

League position and match context are decisive inputs. A team fighting relegation defends differently from one chasing European qualification — and our model accounts for that pressure. Check the live Primera Division de Mexico standings and the Primera Division de Mexico form table to understand exactly where Santos Laguna and Atletico San Luis sit and what this result means for both clubs.

Prediction Accuracy & Track Record

Betiball.com publishes a weekly prediction accuracy review so you can verify our historical hit rate across 1x2, Over/Under, and BTTS markets. We do not hide results that went against our tip — full transparency on model performance is a core part of how Betiball.com operates. Our Primera Division de Mexico predictions are among the highest-rated by our users precisely because the data is always shown alongside the recommendation.

Explore More Primera Division de Mexico Predictions

Find every upcoming Primera Division de Mexico fixtures and predictions for this matchday, or browse all football predictions for today across every major league on Betiball.com.

View More View Less