Napoli vs Pisa: Prediction, Betting Tips & Match Preview – 22 September

Betiball's prediction for Napoli vs Pisa on 22 September 2025 (kick-off: 14:45) is built from both teams' recent form, head-to-head history, squad availability, and tactical analysis. Read the full Napoli vs Pisa preview before placing your bet.

Napoli vs Pisa: Starting Lineups Time : 22/09/2025 14:45

Napoli
3 - 2
Finished
Pisa
82' event Lorenzo Lucca
81' event Juan Guilherme Nunes Jesus / Alessandro Buongiorno
78' event Lorenzo Lucca / Rasmus Hojlund
73' event Leonardo Spinazzola
68' event Leonardo Spinazzola
58' event Andre Zambo Anguissa / Elif Elmas
58' event Stanislav Lobotka / Billy Gilmour
39' event Billy Gilmour
event 90' Lorran Lucas Pereira de Sousa
event 82' Mateus Lusuardi
event 80' Lorran Lucas Pereira de Sousa / Marius Marin
event 75' Matteo Tramoni / MBala Nzola
event 74' Samuele Angori / Giovanni Bonfanti
event 61' Juan Guillermo Cuadrado Bello / Mehdi Leris
event 61' Henrik Meister / Stefano Moreo
event 60' MBala Nzola
event 50' Antonio Caracciolo
event 10' Mehdi Leris No penalty confirmed
82' event Lorenzo Lucca
event 90' Lorran Lucas Pereira de Sousa
81' event Juan Guilherme Nunes Jesus / Alessandro Buongiorno
event 82' Mateus Lusuardi
78' event Lorenzo Lucca / Rasmus Hojlund
event 80' Lorran Lucas Pereira de Sousa / Marius Marin
73' event Leonardo Spinazzola
event 75' Matteo Tramoni / MBala Nzola
68' event Leonardo Spinazzola
event 74' Samuele Angori / Giovanni Bonfanti
58' event Andre Zambo Anguissa / Elif Elmas
event 61' Juan Guillermo Cuadrado Bello / Mehdi Leris
58' event Stanislav Lobotka / Billy Gilmour
event 61' Henrik Meister / Stefano Moreo
39' event Billy Gilmour
event 60' MBala Nzola
event 50' Antonio Caracciolo
event 10' Mehdi Leris No penalty confirmed
Napoli Napoli
Substitutions
#5 Juan Guilherme Nunes Jesus
#99 Andre Zambo Anguissa
#27 Lorenzo Lucca
#68 Stanislav Lobotka
#7 David Neres Campos
#35 Luca Marianucci
#69 Giuseppe Ambrosino
#26 Antonio Vergara
#70 Noa Lang
#32 Vanja Milinkovic Savic
#3 Miguel Ortega Gutierrez
#17 Mathias Olivera
#25 Mathias Ferrante
#13 Amir Rrahmani
Napoli Napoli Pisa Pisa
18Shots15
6Shots on Goal6
10Fouls18
5Corner Kick3
18Free kick9
1Offside0
1Yellow card2
13Aerial21
4Save3
15Successful Tackles17
8Interceptions7
14Long pass19
2Assist1
2Successful center3
4Substitution5
4Shots off goal3
7Head Success10
8Blocked6
12Tackle16
6Dribbles6
17Throw-in11
595Passes330
118Attacks80
45Dangerous attacks22
4Corner Kicks(HT)2
Pisa Pisa
Substitutions
#11 Juan Guillermo Cuadrado Bello
#9 Henrik Meister
#10 Matteo Tramoni
#3 Samuele Angori
#99 Lorran Lucas Pereira de Sousa
#12 David Nicolas Andrade
#22 Simone Scuffet
#33 Arturo Calabresi
#36 Gabriele Piccinini
#19 Tomas Esteves
#39 Raul Albiol Tortajada
#8 Malthe Hojholt
#21 Isak Vural
Commentary
90' Goal! Lorran Lucas Pereira de Sousa - Pisa
82' Goal! Lorenzo Lucca - Napoli
82' Mateus Lusuardi - Pisa receive a yellow card
81' Napoli — substitution: Juan Guilherme Nunes Jesus / Alessandro Buongiorno
80' Pisa — substitution: Lorran Lucas Pereira de Sousa / Marius Marin
78' Napoli — substitution: Lorenzo Lucca / Rasmus Hojlund
75' Pisa — substitution: Matteo Tramoni / MBala Nzola
74' Pisa — substitution: Samuele Angori / Giovanni Bonfanti
73' Goal! Leonardo Spinazzola - Napoli
68' Leonardo Spinazzola - Napoli receive a yellow card
61' Pisa — substitution: Juan Guillermo Cuadrado Bello / Mehdi Leris
61' Pisa — substitution: Henrik Meister / Stefano Moreo
60' Penalty scored! MBala Nzola - Pisa
58' Napoli — substitution: Andre Zambo Anguissa / Elif Elmas
58' Napoli — substitution: Stanislav Lobotka / Billy Gilmour
50' Antonio Caracciolo - Pisa receive a yellow card
39' Goal! Billy Gilmour - Napoli
10' VAR review - Pisa

How We Build the Napoli vs Pisa Prediction

Betiball.com's prediction for Napoli vs Pisa on 22 September 2025 is generated by a statistical model that processes over 30 data points per match — including each team's last ten results, expected goals (xG), shots on target, defensive line metrics, set-piece vulnerability, and confirmed squad availability. For this fixture, our model also factors in home and away performance splits and any confirmed injuries or suspensions reported within 48 hours of kick-off. Every tip includes a probability percentage — not just a pick, but the data behind it.

Napoli vs Pisa Form Analysis

Heading into this match, both sides carry distinct statistical profiles our model weighs carefully. We assess Napoli's recent home record, scoring rate, and clean sheet frequency against Pisa's away form — particularly goals conceded on the road and their tendency to score or keep clean sheets in away fixtures. Over/Under 2.5 goals, Both Teams to Score (BTTS), and the Asian Handicap line are all evaluated through this lens before a final recommendation is issued.

Context: Standings, Form & What's at Stake

League position and match context are decisive inputs. A team fighting relegation defends differently from one chasing European qualification — and our model accounts for that pressure. Check the live standings and the form table to understand exactly where Napoli and Pisa sit and what this result means for both clubs.

Prediction Accuracy & Track Record

Betiball.com publishes a weekly prediction accuracy review so you can verify our historical hit rate across 1x2, Over/Under, and BTTS markets. We do not hide results that went against our tip — full transparency on model performance is a core part of how Betiball.com operates. Our predictions are among the highest-rated by our users precisely because the data is always shown alongside the recommendation.

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