Lazio vs AS Roma: Prediction, Betting Tips & Match Preview – 21 September

Betiball's prediction for Lazio vs AS Roma on 21 September 2025 (kick-off: 06:30) is built from both teams' recent form, head-to-head history, squad availability, and tactical analysis. Read the full Lazio vs AS Roma preview before placing your bet.

Lazio vs AS Roma: Starting Lineups Time : 21/09/2025 06:30

Lazio
0 - 1
Finished
AS Roma
90+7' event Matteo Guendouzi
88' event Mario Gila
86' event Reda Belahyane
79' event Tijjani Noslin / Pedro Rodriguez Ledesma Pedrito
62' event Valentin Mariano Castellanos Gimenez / Boulaye Dia
46' event Luca Pellegrini / Nuno Tavares
46' event Danilo Cataldi / Nicolo Rovella
14' event Reda Belahyane / Fisayo Dele-Bashiru
event 83' Evan Ndicka
event 81' Konstantinos Tsimikas / Jose Angel Esmoris Tasende
event 81' Neil El Aynaoui / Bryan Cristante
event 73' Baldanzi Tommaso / Matìas Soulè Malvano
event 73' Niccolo Pisilli / Lorenzo Pellegrini
event 66' Artem Dovbyk / Evan Ferguson
event 38' Lorenzo Pellegrini
90+7' event Matteo Guendouzi
event 83' Evan Ndicka
88' event Mario Gila
event 81' Konstantinos Tsimikas / Jose Angel Esmoris Tasende
86' event Reda Belahyane
event 81' Neil El Aynaoui / Bryan Cristante
79' event Tijjani Noslin / Pedro Rodriguez Ledesma Pedrito
event 73' Baldanzi Tommaso / Matìas Soulè Malvano
62' event Valentin Mariano Castellanos Gimenez / Boulaye Dia
event 73' Niccolo Pisilli / Lorenzo Pellegrini
46' event Luca Pellegrini / Nuno Tavares
event 66' Artem Dovbyk / Evan Ferguson
46' event Danilo Cataldi / Nicolo Rovella
event 38' Lorenzo Pellegrini
14' event Reda Belahyane / Fisayo Dele-Bashiru
Lazio Lazio
Substitutions
#11 Valentin Mariano Castellanos Gimenez
#21 Reda Belahyane
#3 Luca Pellegrini
#32 Danilo Cataldi
#14 Tijjani Noslin
#23 Elseid Hisaj
#18 Gustav Isaksen
#25 Oliver Nielsen
#35 Christos Mandas
#22 Matteo Cancellieri
#55 Alessio Furlanetto
#4 Patricio Gabarron Gil,Patric
#66 Pietro Pinelli
#71 Valerio Farcomeni
Lazio Lazio AS Roma AS Roma
10Shots13
2Shots on Goal6
14Fouls22
3Corner Kick6
22Free kick14
0Offside4
1Yellow card1
2Red card0
25Aerial23
5Save2
14Successful Tackles17
8Interceptions11
19Long pass25
0Assist1
3Successful center4
8Shots off goal6
1Hit The Post0
15Head Success9
0Blocked1
8Tackle8
7Dribbles2
14Throw-in20
388Passes408
79Attacks104
30Dangerous attacks49
1Corner Kicks(HT)2
AS Roma AS Roma
Substitutions
#8 Neil El Aynaoui
#12 Konstantinos Tsimikas
#35 Baldanzi Tommaso
#61 Niccolo Pisilli
#9 Artem Dovbyk
#32 Devis Vasquez
#87 Daniele Ghilardi
#95 Pierluigi Gollini
#92 Stephan El Shaarawy
#24 Jan Ziolkowski
#66 Buba Sangare
Commentary
90+7' Matteo Guendouzi - Lazio receive a red card
88' Mario Gila - Lazio receive a yellow card
86' Reda Belahyane - Lazio receive a red card
83' Evan Ndicka - AS Roma receive a yellow card
81' AS Roma — substitution: Konstantinos Tsimikas / Jose Angel Esmoris Tasende
81' AS Roma — substitution: Neil El Aynaoui / Bryan Cristante
79' Lazio — substitution: Tijjani Noslin / Pedro Rodriguez Ledesma Pedrito
73' AS Roma — substitution: Baldanzi Tommaso / Matìas Soulè Malvano
73' AS Roma — substitution: Niccolo Pisilli / Lorenzo Pellegrini
66' AS Roma — substitution: Artem Dovbyk / Evan Ferguson
62' Lazio — substitution: Valentin Mariano Castellanos Gimenez / Boulaye Dia
46' Lazio — substitution: Luca Pellegrini / Nuno Tavares
46' Lazio — substitution: Danilo Cataldi / Nicolo Rovella
38' Goal! Lorenzo Pellegrini - AS Roma
14' Lazio — substitution: Reda Belahyane / Fisayo Dele-Bashiru

How We Build the Lazio vs AS Roma Prediction

Betiball.com's prediction for Lazio vs AS Roma on 21 September 2025 is generated by a statistical model that processes over 30 data points per match — including each team's last ten results, expected goals (xG), shots on target, defensive line metrics, set-piece vulnerability, and confirmed squad availability. For this fixture, our model also factors in home and away performance splits and any confirmed injuries or suspensions reported within 48 hours of kick-off. Every tip includes a probability percentage — not just a pick, but the data behind it.

Lazio vs AS Roma Form Analysis

Heading into this match, both sides carry distinct statistical profiles our model weighs carefully. We assess Lazio's recent home record, scoring rate, and clean sheet frequency against AS Roma's away form — particularly goals conceded on the road and their tendency to score or keep clean sheets in away fixtures. Over/Under 2.5 goals, Both Teams to Score (BTTS), and the Asian Handicap line are all evaluated through this lens before a final recommendation is issued.

Context: Standings, Form & What's at Stake

League position and match context are decisive inputs. A team fighting relegation defends differently from one chasing European qualification — and our model accounts for that pressure. Check the live standings and the form table to understand exactly where Lazio and AS Roma sit and what this result means for both clubs.

Prediction Accuracy & Track Record

Betiball.com publishes a weekly prediction accuracy review so you can verify our historical hit rate across 1x2, Over/Under, and BTTS markets. We do not hide results that went against our tip — full transparency on model performance is a core part of how Betiball.com operates. Our predictions are among the highest-rated by our users precisely because the data is always shown alongside the recommendation.

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